Within the last 25 years, 20 % of the approved medications have got either been recalled or experienced new labels added caution of extreme unwanted effects. 7) Reporting ADR’s is voluntary. Medicines like Vioxx can slide through the cracks when businesses choose to cover up known problems. Who knows just how many lives may have been saved if Merck have been honest from the 1st point it knew something was incorrect? 8) The drugs frequently don’t work. Sidney Taurel, chairman of Eli Lilly, admits The normal Food and Drug Administration approved drug works well on just 50 % of individuals.On July 4 At your final meeting, 2006, based on the total results for all 1050 individuals who had undergone randomization, the info and safety monitoring board recommended that the trial end up being stopped. The final decision by the executive committee to follow the suggestion of the data and safety monitoring panel was made on July 15, 2006. Evaluation of the primary end stage was performed with the log-rank test. All secondary end factors were analyzed with a continuity-corrected chi-square check. Nine prespecified subgroup analyses16 and one post hoc subgroup evaluation were performed. Missing end-stage data were imputed according to a worst-case situation. All analyses were performed by using SAS software, version 8.02.