The most recent content by Dr. Marco Leyton, of the Montreal Neurological Institute , McGill University and the McGill University Wellness Centre, which was released in the journal Biological Psychiatry on May 15, 2009, not merely demonstrates a connection between cocaine and the incentive circuits in the mind but also associates the susceptibility to addiction with these mechanisms. The results of this study display that sniffing cocaine triggers high levels of dopamine secretion in a central region of the brain known as the striatum.Our email address details are in keeping with those from four little studies which were performed by using a different preparation of intravenous iron.16-19 One of these studies15 recruited a subgroup of individuals without anemia who had even higher hemoglobin levels than our patients . We do not know the limit of hemoglobin up to which iron deficiency is pathophysiologically important. Based on our current results, we can not recommend treatment with ferric carboxymaltose for sufferers who have chronic heart failing, iron deficiency, and a hemoglobin level above 135 g per liter, but such therapy can be an certain market for future research. In conclusion, in stable, symptomatic, ambulatory individuals with chronic heart failure, an impaired remaining ventricular ejection fraction, and iron insufficiency, treatment with ferric carboxymaltose more than a 24-week period improves symptoms, physical performance, and the quality of life and has acceptable side-effect and adverse-event profiles.