Nevertheless, it is unclear whether the enzymes that modify DNA in this manner target particular genes or whether random modifications select cells for improved tumorigenic capactiy. In fresh research, Rudolf Jaenisch and colleagues, at the Whitehead Institute in Cambridge, Massachusetts, investigated DNA methylation in a mouse style of colon malignancy. They discovered that a DNA methylating enzyme, Dnmt3b, targeted specific genes for silencing, and these genes were comparable to those silenced in individual tumors.Kaiser Family members Foundation. Kaiser Health Information, an independent news service editorially, is a scheduled program of the Kaiser Family Foundation, a nonpartisan healthcare policy research organization unaffiliated with Kaiser Permanente.. S. Dabrafenib is not approved or licensed anywhere in the world for make use of in this treatment setting. The Breakthrough Therapy designation was based on interim efficacy and basic safety results from an ongoing Phase II study of dabrafenib administered orally to 25 patients who experienced NSCLC with the BRAF V600E mutation and who got received at least one previous span of chemotherapy. These interim results were provided at the 2013 American Society for Clinical Oncology Annual Meeting.