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ALKBH7 protein plays key role in controlling programmed necrosis pathway When cells suffer an excessive amount of DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, tumor cells often ignore these signals, flourishing after chemotherapy drugs have got ravaged their DNA even. A fresh finding from MIT researchers may offer a method to overcome that level of resistance: The team has identified a key protein in an alternative death pathway referred to as programmed necrosis.