In addition, the small size of the homozygous subgroup warrants caution in interpreting these results., and Desk S3 in the Supplementary Appendix).12 for tendency), the COWAT score , or the JLO rating , although significance was reached for homozygotes, in comparison with non-carriers, for the MMSE rating and the JLO score . In addition, our model-predicted memory decline coincided with the predictions of Corder et al. Additional lines of evidence support this explanation.16 A report of subjects with such a pattern of memory decline showed a reduced cerebral metabolic rate for glucose patterns in cortical regions that overlap those known to be suffering from Alzheimer’s disease.32 The findings we survey here coincide with temporally, and so may be the cognitive correlate of, this presymptomatic disease stage.The educational authors had full usage of the data and drafted the manuscript. The initial and last authors made the decision to post the manuscript for publication, with approval of the sponsors. An employee of Publication Planning Services provided editorial and writing support, funded by Sanofi and Regeneron Pharmaceuticals. All the authors attest to the precision and completeness of the data and the analyses as offered and for the fidelity of the analysis to the trial protocol, which is available at NEJM.org.