Loss of estrogen and progesterone receptors on tumor cells is associated with poor clinical result. The odds of having ER-negative tumors were 3 x greater for African-American women than for white women nearly. The odds of having a PR-unfavorable tumor were a lot more than 3 x greater for African-American females than for white women. Mitosis: active cell division as dependant on looking at the malignancy cells under a microscope. Tumors with a higher mitotic count are more aggressive. The odds of experiencing a tumor with a high mitotic count were three times greater for African-American females than for white ladies. P53: a protein product made by the p53 tumor-suppressor gene. When detected in huge amounts, it is often connected with unusual function of p53 and loss of cell-cycle control, which can lead to cancer.Risk-factor position or level was classified in aggregate, relative to our previously published algorithm,2,7 into five mutually exclusive categories , one where all risk elements were optimal, another where at least one risk factor was not optimal, a third in which at least one risk aspect was elevated, a fourth in which one major risk factor was present, and a fifth in which several major risk factors were present. Descriptions of secondary analyses are included in the Supplementary Appendix. All references to estimates of lifetime risk reflect those produced from the 17 studies in the pooled cohort, after the exclusion of data from individuals in MRFIT, apart from race-specific estimates for guys, which were derived from MRFIT.