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Two-sided P ideals had been calculated, and a significance threshold of P<0.01 was used to correct for multiple hypotheses assessment for the five CYP genes.24 Hazard ratios and 95 percent confidence intervals had been calculated on the basis of Cox proportional-hazards regression models with clinical syndrome as a stratification factor. A two-sided P value was used to test for significance . If a significant relationship between genotype classification and the primary efficacy final result was identified, we explored additional efficacy outcomes after that, including components of the composite primary efficacy outcome and stent thrombosis. Sensitivity analyses comparing CYP2C19*2 carriers with non-carriers were performed in the same way.