Neither of these parties endorse or recommend any commercial products, services, or equipment.. Acute levodopa might worsen engine plasticity in late-stage PD By Lauretta Ihonor Administering severe doses of levodopa appears to worsen electric motor cortex plasticity as Parkinson’s disease advances, researchers report. They say that ‘repeated non-physiological surges in synaptic dopamine during severe [levodopa] dosing could potentially result in persistent dysfunction of important enzymes of the intracellular signalling cascade that are involved in the induction and maintenance of both forms of plasticity.’ Motor problems are recognized to develop in response to levodopa therapy as PD progresses.Antitrust review Abbott has announced that the waiting period beneath the Hart-Scott-Rodino Antitrust Improvements Take action of 1976 applicable to Abbott’s money tender offer to purchase all of the outstanding shares of common stock of Advanced Medical Optics expired last night in 11:59 p.m. Eastern time. The expiration of the HSR waiting around period satisfies one of the conditions necessary for the consummation of the tender present. The tender present is planned to expire at midnight Eastern time on Tuesday, Feb. 24, 2009, unless the tender present is prolonged. Consummation of the tender offer remains at the mercy of other customary circumstances, including European Commission merger control clearance and the tender of a majority of the exceptional shares of AMO’s common share on a completely diluted basis.