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None of the other medicines examined, including propofol, dexmedetomidine, and opiates, were consistently connected with global cognition or executive-function outcomes. Sensitivity analyses that included only individuals for whom complete final result data were available yielded similar results . Furthermore, modifications for an altered level of consciousness and surgical versus medical ICU didn’t qualitatively change our findings. Discussion In this multicenter, prospective cohort research involving a diverse population of patients in general surgical and medical ICUs, we found that one out of four individuals had cognitive impairment 12 months after critical illness that was similar in severity to that of sufferers with mild Alzheimer’s disease, and one out of three had impairment associated with moderate traumatic mind injury typically.